§ 69403.8. Immunotoxicity.

Latest version.

(a) Immunotoxicity is defined as the occurrence of adverse effects on the components or function of the immune system following exposure to a chemical substance.
(b) Toxicological endpoints for immunotoxicity include but are not limited to those indicating: allergic sensitization, those indicating hypersensitivity (types I-IV); changes in circulating immune cell numbers; gross and histopathological changes in lymphoid organs; alterations in cytokine production and release; changes in number or behavior of regulatory effector cells; in vivo suppression or enhancement of the immune response; changes in specific immunoglobulins; changes in immune organ weights; in vitro or ex vivo indicators of heightened or suppressed immune response; initiation or exacerbation of autoimmunity.
(c) Other relevant immunotoxicity data include but are not limited to: high antigenicity; structural or mechanistic similarity to other chemical substances that are immunotoxic.

HISTORY

1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).

Note

Note: Authority cited: Sections 25256.1 and 59012, Health and Safety Code. Reference: Sections 25256.1 and 59012, Health and Safety Code.

                    
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