§ 69403.9. Musculoskeletal Toxicity.

(a) The musculoskeletal toxicity hazard trait is defined as the occurrence of adverse effects on the structure or function of the musculoskeletal system following exposure to a chemical substance. The musculoskeletal system includes bones, muscles, cartilage, tendons, ligaments, joints and connective tissue.

(b) Toxicological endpoints for musculoskeletal toxicity include, but are not limited to those indicating: necrosis, inflammation, discomfort or pain of the musculoskeletal system; arthritis; decreased joint movement; changes in mineral content of bone including tooth mottling; osteomalacia; osteoporosis; bone malformation or other skeletal growth disorders; abnormal bone mass or density indices; tooth loss; cell proliferation or altered ratio of musculoskeletal cells; fibromyalgia; adverse muscle or neuromuscular function.

(c) Other relevant musculoskeletal toxicity data include, but are not limited to: in vitro indicators of musculoskeletal toxicity; structural or mechanistic similarity to other chemical substances that are toxic to the musculoskeletal system.

HISTORY

1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).

Note

Note: Authority cited: Sections 25256.1 and 59012, Health and Safety Code. Reference: Sections 25256.1 and 59012, Health and Safety Code.