§ 69403.15. Reactivity in Biological Systems.

Latest version.

(a) The reactivity in biological systems hazard trait is defined as the occurrence of rapid reactions with molecules in the body that lead to alterations in critical molecular function and ultimately adverse health outcomes.
(b) Toxicological endpoints for reactivity in biological systems include, but are not limited to: covalent binding to or oxidation of cellular macromolecules; in vivo generation of reactive oxygen species or oxidative stress; catalytic generation of hydroxyl radicals in vivo.
(c) Other relevant data include, but are not limited to: in vitro measurements of covalent binding to or oxidation of DNA, lipids or proteins; detection of reactive species in cell culture; structural or mechanistic similarity to other chemical substances that are reactive in biological systems.

HISTORY

1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).

Note

Note: Authority cited: Sections 25256.1 and 59012, Health and Safety Code. Reference: Sections 25256.1 and 59012, Health and Safety Code.

                    
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