§ 69403.4. Epigenetic Toxicity.

Latest version.

(a) The epigenetic toxicity hazard trait is defined as changes, at the cellular or organism level, in gene expression or gene function that do not involve changes in the DNA sequence and contribute to adverse effects in an organism following exposure to a chemical substance.
(b) Toxicological endpoints for epigenetic toxicity include, but are not limited to those indicating: toxicity in humans or animals associated with epigenetic mechanisms such as chemically induced DNA methylation, histone modification, nucleosome remodeling, or non-coding RNA. Chemically induced epigenetic endpoints may be observed in an exposed organism or its offspring.
(c) Other relevant epigenetic toxicity data include but are not limited to: in vitro or other data using biological models indicative of chemically induced epigenetic toxicity in an exposed organism or its offspring; structural or mechanistic similarity to other chemical substances that induce adverse epigenetic effects.

HISTORY

1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).

Note

Note: Authority cited: Sections 25256.1 and 59012, Health and Safety Code. Reference: Sections 25256.1 and 59012, Health and Safety Code.

                    
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