§ 69403.3. Endocrine Toxicity.

(a) The endocrine toxicity hazard trait is defined as the occurrence of adverse effects following exposure to a chemical substance on the structure or function of the endocrine system, including endocrine disruption and metabolic syndrome.

(b) Toxicological endpoints for endocrine toxicity include but are not limited to those indicating: adverse effects on endocrine organs; adverse perturbations of the synthesis, secretion, transport, binding, action, or elimination of natural hormones or their receptors in the body that are responsible for the maintenance of homeostasis, metabolism, reproduction, development or behavior.

(c) Other relevant data include but are not limited to: binding of a chemical substance or its metabolites to hormones or hormonal receptors or inhibition of hormone synthesis in vitro experimental models; induction of hormone metabolic enzymes; modulation of genes involved in metabolic syndrome; structural or mechanistic similarity to other chemical substances that are toxic to endocrine systems.

HISTORY

1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).

Note

Note: Authority cited: Sections 25256.1 and 59012, Health and Safety Code. Reference: Sections 25256.1 and 59012, Health and Safety Code.