§ 69402.3. Developmental Toxicity.

(a) The developmental toxicity hazard trait is defined as the occurrence of adverse effects on the developing organism following exposure to a chemical substance prior to conception (either parent), during prenatal development, or postnatally to the time of sexual maturation. Developmental toxicity occurs during the postnatal period only if the developing organism shows greater quantitative or qualitative susceptibility to the chemical substance than does the adult organism.

(b) Toxicological endpoints for developmental toxicity include but are not limited to those indicating: death of the developing organism, structural abnormality, altered growth, functional deficiency or other adverse effect on the developing organism. These observations in animals or humans can be manifested at any point in the lifespan of the organism or its offspring.

(c) Other relevant data include, but are not limited to: mechanistic data at the molecular level such as genotoxicity or epigenetic toxicity, or at the cellular, organ, or organism level; structural or mechanistic similarity to other chemical substances that are toxic to developing organisms.

HISTORY

1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).

Note

Note: Authority cited: Sections 25256.1 and 59012, Health and Safety Code. Reference: Sections 25256.1 and 59012, Health and Safety Code.